Define Factor xiiia. Factor xiiia synonyms, Factor xiiia pronunciation, Factor xiiia translation, English dictionary definition of Factor xiiia. Noun 1. factor XIII - in the 

Coagulation factor XIIIa (FXIIIa) is a transglutaminase that covalently cross-links fibrin and other proteins to fibrin to stabilize blood clots and reduce blood loss.

Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot. Factor XIII (FXIII) is a key molecule in the field of blood coagulation and in the last decades it has weakened attention within the field of angiogenesis and tissue repair. FXIII positively influences wound healing in several tissues by exerting multiple plasma and cellular functions. Human Factor XIII is cleaved with human alpha thrombin. The thrombin is subsequently removed via chromatography.

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El factor de coagulación XIII, factor XIII, factor estabilizador de la fibrina o factor de Laki-Lorand es una proteína plasmática de síntesis hepática y plaquetaria, que participa en la ruta final común de la hemostasia, estabilizando el coágulo blando de fibrina o polímero de fibrina Factor XIIIa rapidly cross-links α2-antiplasmin to the α-chain of fibrin.67,68 This cross-linking reaction occurs between Gln2 in the amino terminus of α2-antiplasmin69 and Lys303 in the fibrin α-chain.68 The α2-antiplasmin remains an efficient plasmin inhibitor when covalently cross-linked to fibrin, and incorporation of the inhibitor into the clot by factor XIII plays a major role in Factor XIIIaは、血液凝固因子の一つで、真皮の間質の樹枝状細胞や紡錘形細胞の一部で陽性となる。 皮膚科領域では、Dermatofibroma(DF)とDermatofibrosarcoma protuberans(DFSP)の鑑別に用いられる。 Our Factor XIIIa Antibodies can be used in a variety of model species: Human. Use the list below to choose the Factor XIIIa Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Factor XIII is a betaglobulin found in plasma and is composed of two subunits. Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000.

S100 protein was expressed by 100% of neurofibromas, schwannomas, and melanocytic nevi. Our findings suggest that factor XIIIa may provide a reliable and  

Factor XIIIa, which is activated from factor XIII by thrombin, crosslinks fibrin. Färg på  Engelska.

S100 protein was expressed by 100% of neurofibromas, schwannomas, and melanocytic nevi. Our findings suggest that factor XIIIa may provide a reliable and  

According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W. 320,000); whereas in platelets, only the alpha2 unit exists. As you have mentioned in your e-mail, dendritic cells also express Factor XIIIa. However, the expressed levels of Factor XIIIa may be different from that in the placenta which usually shows very high levels of this protein.

Factor XIIIa immunolabeling appears heterogeneous in the early andlate fetal tissues, in rounded and dendritic cells. Some cells express Factor XIIIa and certain monocyte markers. They are identified in close association with blood The specificity of this monoclonal antibody to human Factor XIIIa was validated by HuProtTM Array, containing more than 19,000, full-length human proteins.
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The activated Factor XIII (XIIIa) acts on fibrin (Factor Ia) to form γ-glutamyl-Є-lysyl amide cross links between fibrin molecules leading to the formation of an insoluble clot. Factor XIII (FXIII), or fibrin stabilizing factor, deficiency was first reported in the literature in 1960. It is the rarest factor deficiency, occurring in 1 per 5 million births.

It is a Ca 2+ -dependent transglutaminase or transamidating enzyme which forms intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules resulting in the mechanical stabilization of the fibrin clot and its resistance to proteolysis. Factor XIIIa is a transglutaminase that catalyzes the formation of covalent bonds between lysine and activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is Define Factor xiiia. Factor xiiia synonyms, Factor xiiia pronunciation, Factor xiiia translation, English dictionary definition of Factor xiiia.
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We found that, similar to insect transglutaminase, the human homologue factor XIIIa also has an immune function. Since transglutaminase protects insects 

Factor XIII of human blood is a Factor XIIIa (AC-1A1) is a highly sensitive marker of sebaceous differentiation. It may have potential clinical utility as a specific marker to distinguish sebaceous carcinoma from poorly differentiated SCC. Coagulation Factor XIIIA (F13A1): Novel Perspectives in Treatment and Pharmacogenetics. Gemmati D(1), Vigliano M, Burini F, Mari R, El Mohsein HH, Parmeggiani F, Serino ML. Author information: (1)Centre Hemostasis & Thrombosis - Unit of Haematology, Department Medical Sciences, University of Ferrara, I-44100, Ferrara Italy. d.gemmati@unife.it. A large number of fibroblast-like and pleomorphic cells express factor XIIIa in MFH. The cytological pleomorphism of factor XIIIa cells suggests that these cells may belong to the neoplastic population.